Issue Area - Medication Compliance
Clinical and Economic Advantages of Modern Dosage Forms: Improving Medication Adherence, by Albert Wertheimer, MBA, PhD, 2006
A substantial source of waste and inefficiency in health care is patient non-adherence with medications. Modern drug delivery technology can help improve adherence by simplifying the dosing regimen, and/or decreasing side effects. Other advantages include steadier drug concentrations in the bloodstream and targeted delivery of medication to its site of therapeutic action in the body.
Compliance Navigator Software, 1997 (downloadable)
Access to a Meta-Analysis of Research on Improving Medication
Compliance
This software enables the user to examine key compliance literature abstracts in a number of ways, including comparing the effectiveness of the intervention and sorting the data by disease. Enables the user to focus on abstracts of interest.
Drug Delivery Systems Improve Pharmaceutical Profile and Facilitate Medication Adherence, by Albert I. Wertheimer, MBA, PhD, et al., Advances in Therapy, Vol. 22, No. 6, November/December 2005
Innovations in dosage forms and dose delivery systems across a wide range of medications offer substantial clinical advantages, including reduced dosing frequency and improved patient adherence; minimized fluctuation of drug concentrations and maintenance of blood levels within a desired range; localized drug delivery; and the potential for reduced adverse effects and increased safety. The advent of new large-molecule drugs for previously untreatable or only partially treatable diseases is stimulating the development of suitable delivery systems for these agents. Although advanced formulations may be more expensive than conventional dosage forms, they often have a more favorable pharmacologic profile and can be cost-effective. Inclusion of these dosage forms on drug formulary lists may help patients remain on therapy and reduce the economic and social burden of care. This file is posted here with permission of Health Communications Inc., the publisher of Advances in Therapy®. It is provided for individual use only and may not be used for commercial distribution.
Effectiveness of Interventions to Improve Patient Compliance: A Meta-analysis, by Debra Roter, et al., Medical Care, Vol. 36, No. 8, August 1998
This NPC funded research found that comprehensive compliance interventions work best. The statistical analysis of 153 studies showed that combining several approaches were more effective.
Ethnic Disparities in the Burden and Treatment of Asthma, 2005
In the United States the burden of asthma falls disproportionately on the black and Hispanic—largely Puerto Rican—populations, especially children. Much of this disparity has been attributed to unequal access to preventive care. Black and Puerto Rican children characteristically under-use routine health care services and overuse emergency care services for asthma. This report, developed in partnership with the Asthma and Allergy Foundation of America, discusses: disparities in the burden of asthma; possible hereditary, environmental, and behavioral causes of these disparities; and ways in which these asthma disparities may be lessened.
Annotated PowerPoint slides related to this report are available.
Noncompliance with Medications: An Economic Tragedy with Important Implications for Health Care Reform, 1994
The economic and medical consequences of noncompliance to the U.S. health care system are examined in this 32-page NPC publication. Understand how noncompliance accounts for up to $100 billion in health care and productivity costs.
Patient Adherence to HIV Medication Regiments: A Review of Published and Abstract Reports, by Linda Fogarty, et al., Patient Education and Counseling, Vol. 46 2002
A literature search of published articles reporting correlates of HIV medication adherence or interventions designed to increase HIV medication adherence found that more complex regimens were related to decreased adherence, but were often successfully mitigated by medication aids. Social and psychological factors reflecting emotional adjustment to HIV/AIDS and provider support were related to adherence. Access to institutional resources was also associated with better adherence.
Urinary Incontinence: Economic Burden and New Choices in Pharmaceutical Treatment, by Richard Levy, PhD and Nancy Muller, Advances in Therapy, Vol. 23, No. 4, July/August 2006
In the year 2000, an estimated 17 million community-dwelling adults in the United States had daily urinary incontinence (UI) and an additional 33 million suffered from the overlapping condition, overactive bladder. Estimates of the total annual cost of these conditions range up to $32 billion. Until recently, pharmaceutical therapy for UI has been limited, especially because the adverse effects of available agents resulted in poor adherence to treatment regimens. Recent innovations in molecular design and new dosage forms of UI medications offer the promise of fewer and less severe adverse effects and, thus, better treatment outcomes for patients. New pharmacologic treatment options for UI have the potential to allow greater independence for older persons who reside at home and to delay or avoid the costs of admission to long-term care facilities. This file is posted here with permission of Health Communications Inc., the publisher of Advances in Therapy®. It is provided for individual use only and may not be used for commercial distribution.
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