News from Thursday, September 7, 2023
Articles
Report Stresses Value of Innovative Medicines to Patients and Society
(9/7, The Pharma Letter) reports “...One flaw pointed out with the ICER model is the assumption that a drug will always cost whatever its list price was during the first year it became available—and it only calculates value for patients that start taking it in that year. This disregards how drug prices fall over time, according to No Patient Left Behind.” Subscription Required
Differentiated Service Delivery Models Have Comparable Effectiveness to Standard of Care in HIV
(9/6, Julia Bonavitacola, The American Journal of Managed Care) reports “Differentiated service delivery (DSD) models were able to provide comparable effectiveness in treating people with HIV as the standard of care (SoC) when it came to maintaining care and viral suppression, according to a review published in Reviews in Medical Virology.” Full
AstraZeneca CEO Pascal Soriot Proposes a Novel Fix to the Drug Pricing Law's Alleged Cancer Problem
(9/6, Jason Mast, STAT Plus) reports “...On Wednesday, AstraZeneca CEO Pascal Soriot proposed a new solution...[AstraZeneca CEO Pascal Soriot] said Congress could fix the issue by just changing when the countdown to drug negotiation begins. Instead of starting the 9- or 13- year clock when a drug is first approved, Medicare should start the clock once a drug loses its ‘orphan’ status - i.e. ‘once you get a new indication and treat more than 200,000 patients,’ Soriot said.” Subscription Required
Gilead-Backed Study Warns IRA Price Negotiations Could Hit R&D Harder Than Expected
(9/6, Nick Paul Taylor, Fierce Biotech) reports “...The U.S. Congressional Budget Office previously ran the numbers on the IRA, concluding that 15 out of 1,300 drugs would not come to market over the next 30 years. However, multiple analyses have called the CBO figures into question, with healthcare consulting firm Avalere, which received money from Gilead Sciences, finding the IRA could cut pharma revenues by $450 billion and another analysis suggesting between 24 and 49 currently available therapies wouldn't have reached the market if the pricing provisions took effect in 2014.” Full
Press Releases
ICER Names Roberta Herman, MD, to Governance Board
(9/7, ICER Press Release) “...Dr. Herman is the CEO and President of the Joslin Diabetes Center; previously she also served on their Board of Trustees. Dr. Herman has significant experience in health policy and payer sectors as well. For four years, she was the Executive Director of the Group Insurance Commission (GIC) under the Baker Administration; a quasi-independent $2B+ agency that procures and administers health insurance and other benefits for more than 450,000 employees and retirees for Commonwealth of Massachusetts and their dependents. Dr. Herman also co-led the Healthcare Value Transformation Practice at Navigant (now Guidewell).” Full
OM1 Launches Parkinson’s Disease Premium Dataset to Expand Real-World Evidence in Neuroscience
(9/1, OM1 Press Release) “...The dataset includes more than 7,000 patients prospectively followed by neurologists in hundreds of clinics across all 50 states. To enrich the data, OM1 extracts relevant information from treating clinician notes using its unique artificial intelligence (AI) and language modeling capabilities. Data points include key symptoms, disease severity, treatments, longitudinal outcomes, and clinical response. In addition to the premium dataset, data from an additional 700,000 PD patients are available in the OM1 Real-World Data Cloud™ for modeling health economics outcomes, patient recruitment for clinical trials, prescriber trends, and other research needs.” Full
Journals
Comparative Effectiveness of Upadacitinib Versus Ustekinumab for Ulcerative Colitis: A Multicenter Retrospective Cohort Study
Rahul S Dalal, et al.
September 4, 2023, Clinical Gastroenterology and Hepatology
Comparative Effectiveness of Biologic Therapies in Preventing Penetrating Complications in Patients with Crohn's Disease
Jeffrey D McCurdy, et al.
September 4, 2023, Clinical Gastroenterology and Hepatology